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KMID : 1140120110160020110
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Cancer Prevention Research
2011 Volume.16 No. 2 p.110 ~ p.117
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Effects of Curcumin on Growth Inhibition and Visfatin Expression in Human Breast Cancer Cells
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Kang Yong-Gyu
Kim Su-Ryun
Bae Moon-Kyung
Yun Il
Jang Hye-Ock
Bae Soo-Kyung
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Abstract
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Curcumin has been actively investigated as an anti-cancer drug since it induces cell growth inhibition and apoptosis in many cancer cells. Curcumin acts through modulation of multiple pathways and genes. In this study, curcumin inhibited MDA-MB-231 breast cancer cell growth, which was accompanied by induction of apoptosis and reduction of visfatin gene expression. The MDA-MB-231 cells transfected with visfatin siRNA displayed enhanced sensitivity in growth inhibition to curcumin, whereas cells treated with visfatin protein attenuated curcumin-induced cell growth inhibition in MDA-MB-231 cells. We therefore suggest that the decrease of visfatin by curcumin may contribute to the inhibition of breast cancer cell growth.
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KEYWORD
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Visfatin, Curcumin, Breast cancer cells
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